"As we continue to make large strides in our understanding of memory loss and dementia in aging, we have renewed confidence that we will be able to work towards a more individualized approach to preventions and treatments," said Schneider.
Funding included grants from NIH: U01AG016976, P01AG003949, R01AG03749, P50AG016574, R01AG054449, P30AG028303, P30AG012300, P30AG049638, P30AG010124, P30AG010161, P50AG047366, P50AG025688, P50AG005131, R37AG011378, R01AG041851, R01AG042210, R01AG017917, R01AG034374, UF1AG053983 and UF1AG057707. "Researchers define Alzheimer's-like brain disorder: LATE symptoms resembles Alzheimer's disease but has different cause." Science Daily. The accumulation of beta-Amyloid and tau proteins in the brain is hallmark pathology for Alzheimer disease.
Alzheimer's, the most common form of dementia, causes loss of cognitive functions -- especially memory, but also -- results in changes in everyday functional abilities and behavior.
In the past, most cases of dementia with memory loss were assumed to be Alzheimer's disease.
Abnormal TDP-43 was first recognized in amyotrophic lateral sclerosis and frontotemporal lobar degeneration, relatively uncommon diseases.
Recent research shows that misfolded TDP-43 protein is very common in older adults.These Alzheimer's treatments boost performance of chemicals in the brain that carry information from one brain cell to another.However, these treatments don't stop the underlying decline and death of brain cells.Recently developed positron emission tomography (PET) tracers, including [18F]-AV-1451, ...The National Academy of Sciences Board on Behavioral, Cognitive, and Sensory Sciences (BBCSS) invites scientists to submit white papers on the topic of Alzheimer’s disease and Alzheimer’s disease-related dementias in the first phase of a new decadal survey aimed at reducing the burden of these diseases.Researchers call for removing people with LATE from studies of Alzheimer's drugs A key recommendation was for routine autopsy evaluation and classification of LATE.The researchers suggest the autopsy diagnosis be in three stages, according to where in the brain TDP-43 is detected: Additional recommendations include highlighting the great need for the development of biomarkers to increase recognition during life, further pathological studies, and the generation of new animal models for studying LATE.A growing understanding of how the disease disrupts the brain has led to potential Alzheimer's treatments that short-circuit basic disease processes.Future Alzheimer's treatments may include a combination of medications, similar to how treatments for many cancers or HIV/AIDS include more than a single drug.More The National Academy of Sciences Board on Children, Youth, and Families (BCYF) has released a report of a consensus study on reducing child poverty in the United States, thanks in part to key leadership by psychological scientists.Current Alzheimer's treatments temporarily improve symptoms of memory loss and problems with thinking and reasoning.